Tumor cells and the components of TME, including CD8+ T cells [6, 7], CD4+ T cells [8, 9], NK cells [10], dendritic cells [11, 12], B cells [13, 14], macrophages [15], FOXP3 [16], and Collagen I [17] have close correlations to tumor treatment and prognosis. Here, CD4 is linked to neoplasm.