The DAMPs including advanced glycation end products (AGEs), high mobility group box-1 (HMGB1), soluble CD163 (sCD163), macrophage migration inhibitory factor (MIF), and neutrophil extracellular trap (NET) have been implicated in AOSD pathogenesis [1–2, 11, 58]. The gene discussed is MIF; the disease is adult-onset Still disease.