The DAMPs including advanced glycation end products (AGEs), high mobility group box-1 (HMGB1), soluble CD163 (sCD163), macrophage migration inhibitory factor (MIF), and neutrophil extracellular trap (NET) have been implicated in AOSD pathogenesis [1–2, 11, 58]. This evidence concerns the gene HMGB1 and adult-onset Still disease.