In patients with Henoch-Schönlein purpura (HSP) or asthma, methylation-based silencing of the related genes (e.g., Foxp3, suppressor of cytokine signaling 1 (SOCS1), and SOCS3) disturbed the Treg/Th17 cell balance and critically contributed to pathogenesis of related diseases [52]. The gene discussed is SOCS1; the disease is hereditary spastic paraplegia.