ACE2 and severe acute respiratory syndrome: In this regard, Chan and coauthors examined seven established human intestinal cell lines, DLD-1, HCT-116, HT-29, LoVo, LS-180, SW-480, and SW-620, for their susceptibility to SARS-CoV infection and found that only LoVo cells, which express intermediate levels of ACE2, were permissive.