In addition, a recent study has implied that MYC and TWIST1 are essential for the activation of innate immunity and cellular invasion, as the recruitment and polarization of tumor-associated macrophages (TAMs) require a certain cytokinome elicited by them, and overexpression of TWIST1 could promote metastasis in hepatocellular carcinoma [10]; meanwhile in another study, inactivation of PLOD3 is found to inhibit in vitro and in vivo liver tumorigenesis in hepatocellular carcinoma [11]. This evidence concerns the gene PLOD3 and neoplasm.