NPPB and heart failure: The outcomes included a composite of cardiovascular death or hospitalization for worsening heart failure [three RCTs (11, 12, 21)], hospitalization for worsening heart failure [three RCTs (11, 12, 21)], change in KCCQ score [three RCTs (11, 12, 14)], change in NT-proBNP from baseline [five RCTs (11–14, 22)], change in 6MWT from baseline [three RCTs (14, 15, 22)], and change in body weight from baseline [four RCTs (11–13, 15)].