MCM4 and osteosarcoma: We found that MCM4 played a core role in all analyses (using ONCOMINE, GEPIA, PROGNOSIS biomarker and KEGG datasets) and the differential expression of MCM4 in osteosarcoma cell line was confirmed using qRT-PCR and western blot, this has led us to further explore the mechanism of prognostic value of MCM4 in sarcoma.