Then, to explore the function of SNHG12 in the ability of ICC cells, we down-regulated SNHG12 expression in CCLP1 and TFK-1 cells using sh-SNHG12-1 and sh-SNHG12-2, which was confirmed by RT-PCR (Figure 1C). This evidence concerns the gene PPFIBP2 and intrahepatic cholangiocarcinoma.