In COVID-19 patients experiencing respiratory failure, immune responses are reported to be universally classified by either MAS (based on ferritin > 4,420 ng/ml) or immune dysregulation similar to septic immunoparalysis (based on HLA-DR on CD14 monocytes <5,000), representing about 25 and 75% of patients, respectively. This evidence concerns the gene CD14 and COVID-19.