Taken together, increasing severity in COVID-19 appears to be associated with a reduction in NK cells, profound lymphopenia, increased proliferation and activation of CD14+CD16+ inflammatory monocytes with reduced antigen-presentation markers, increased cytokine release, elevated acute-phase reactants, and expression of chemokines that mediate the recruitment of inflammatory monocytes, macrophages, and neutrophils to infected tissue. Here, CD14 is linked to COVID-19.