On the contrary, other studies developed with multicellular spheroids also have demonstrated that when hypoxia–reoxygenation is induced, the levels of vascular endothelial growth factor (VEGF) are downregulated by the tumor cells, as well as it activated DNA damage repair markers (Kondoh et al., 2013; Riffle et al., 2017). The gene discussed is VEGFA; the disease is neoplasm.