In contrast, the highly virulent isolate Nc-Spain7 induced higher IFN-γ production by stimulated blood cells at the first week of infection, predominating over IL-4, which was observed previously and may be attributed to its higher proliferation capacity (Regidor-Cerrillo et al., 2014; Jiménez-Pelayo et al., 2017; García-Sánchez et al., 2019b). The gene discussed is IL4; the disease is infection.