Gianni et al. showed that knockdown of S100A3 leads to degradation of RARα, a transcription factor that plays a role in the antiproliferative effects of All-trans retinoic acid (ATRA) [73], by proteasomes thus inducing resistance to the antiproliferative and differentiating effects of ATRA on lung cancer cells [74]. The gene discussed is S100A3; the disease is lung cancer.