There were no significant between-group differences in SIRT1 gene expression (CTRL = 0.89 ± 0.08; PAH = 0.96 ± 0.12; PAH+RES = 0.82 ± 0.09mRNA/HPRT), while SIRT5 decreased in both the PAH and PAH+RES groups (CTRL = 0.92 ± 0.11; PAH = 0.43 ± 0.08; PAH+RES = 0.45 ± 0.071mRNA/HPRT). Here, SIRT1 is linked to pulmonary arterial hypertension.