Besides, in cell line experiments, ginkgolides, EGCG, and curcumin derivatives accelerate the expression of BDNF in U118MG glioma cells more significantly than in SH-SY5Y neuroblastoma cells, advocating that glioblastoma cells may play crucial roles in the initiation of BDNF gene using phytochemicals [140]. Here, BDNF is linked to central nervous system cancer.