INS and Insulin resistance: Cluster 4 included middle-aged, overweight patients, with shorter disease duration, the highest levels of insulin resistance markers (the highest mean levels of insulin, HOMA-IR, and TYG index), the poorest lipid profile (the highest mean levels of TC, TG, and LDL), increased FG mean level, and moderately high HbA1c mean level (6.5 ≤ HbA1c ≤ 7%).