The top 20 significant terms of the KEGG analysis included endocytosis, Alzheimer's disease, the spliceosome, the mTOR signaling pathway, RNA transport, insulin resistance, autophagy, and the Notch signaling pathway, and these pathways were associated with HSF1 (Figure 7(a)). The gene discussed is HSF1; the disease is early-onset autosomal dominant Alzheimer disease.