JZLGD inhibited the NLRP3/caspase-1/GSDMD-mediated canonical pyroptosis pathway and the LPS/caspase-11/GSDMD-mediated noncanonical pyroptosis pathway, exerting beneficial effects in HFD-fed NAFLD rats. The gene discussed is GSDMD; the disease is metabolic dysfunction-associated steatotic liver disease.