The enrichment analysis results show that HJD intervention and metastatic CM treatment involve multiple cancer signal pathways and signal pathways related to tumor metastasis, including melanoma, bladder cancer, prostate cancer, small cell lung cancer, chemokine signaling pathway, NF-kappa B signaling pathway, p53 signaling pathway, HIF-1 signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer. Here, TP53 is linked to melanoma.