AKT1 and fibrosis: Li et al. speculated that luteolin exhibits antifibrotic effects in HSCs and liver fibrosis by targeting the AKT/mTOR/p70S6K and TGFβ/Smad signaling pathways in CCl4, dimethylnitrosamine, and bile duct ligation induced animal models of fibrosis and rat HSCs and HSC-T6 cells [95].