Chai et al. reported GALNT8 as the oncogene in retinoblastoma that potentially drives the cancer development and progression [25] by directly binding to the GALNT8 promoter and boost the transcription of GALNT8 through TCEA1 (Transcription Elongation Factor A1) recruitment, which mechanistically endorsed our experimental data in CRC. The gene discussed is GALNT8; the disease is retinoblastoma.