During viral infection, various factors including delicate and dynamic equilibrium between pro-inflammatory and anti-inflammatory responses, immune cell activation and deactivation, and IFNs upregulation and IFN-reversion to the baseline, play important roles in viral pathogenesis and progression of disease (Virgin et al., 2009; Osburn et al., 2013; Maarouf et al., 2018; Blanco-Melo et al., 2020). The gene discussed is IFNA1; the disease is viral infectious disease.