Several chemicals and physiological factors trigger the upregulation of DJ-1, which protects the oxidative and endoplasmic reticulum stress-induced damage of endothelial cells, Mφs, fibroblast, NCs, and islet β cells (290–296), and therefore, DJ-1 deficiency has been associated with the development of several diseases (e.g., stroke, male infertility, cancers, diabetes, and neurodegenerative illnesses) (290, 297, 298). This evidence concerns the gene PARK7 and stroke disorder.