Brains of the GBA1 mouse model of PD have shown partial GCase deficiency and its impact on increased production of TNFα, IL-1β, TGFβ1, CCL2, CCL3, CCL5, VCAM-1, ICAM-1, and MCSF as well as their link to the neuronal cell death (Table 3A). The gene discussed is IL1B; the disease is Parkinson disease.