Brain regions and their cells of the mouse model of PARK7-associated PD have shown DJ-1 deficiency and its effect on increased production of IFNγ, IL-1β, IL-1Ra, IL-6, IL-16, IL-17, CXCL11, and NGF as well as on the damage of ACs and DA neurons (Table 7A). The gene discussed is IL1B; the disease is Parkinson disease.