However, the abnormal function of LRRK2, GBA, SNCA, PARK2, PARK6, and PARK7 genes has been linked to alteration in innate and adaptive immune responses in cancer, stroke, diabetes, male infertility, Crohn's disease, and infectious diseases (59, 96–98, 125, 127–133, 237–245, 290, 297, 298, 306–309). The gene discussed is PINK1; the disease is male infertility.