In another study, auraptene from Ferula szowitsiana root indicated anti-tumor activity in human breast cancer cells via up-regulation of caspase-3 and caspase-8 and down-regulation of MMP-9, MMP-2, VEGFR-1 (vascular endothelial growth factor), and VEGFR-2 genes (Charmforoshan et al., 2019). The gene discussed is CASP3; the disease is neoplasm.