MAPK8 and cystic fibrosis: It has been demonstrated that the c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) signaling pathways play important roles in CF proliferation and activation, and that the inhibition of JNK or p38 MAPK signaling ameliorates fibrosis (Meyer-Ter-Vehn et al., 2006; Bansal et al., 2017; Du et al., 2020; Yue et al., 2020).