HMGB1 and inflammatory response: Some studies have found an association of age-related increase in DAMPs circulating levels, such as mitochondrial DNA or high mobility group protein B1 (Davalos et al., 2013; Pinti et al., 2014), with circulating proinflammatory cytokines (TNF-α, IL-6) in humans, suggesting that DAMPs might play a role in low-grade systemic chronic inflammation described in the elderly (Goronzy and Weyand, 2013; Franceschi and Campisi, 2014).