HAVCR1 and acute kidney injury: Some reports have found a lack of difference in initial severity of IRI, as described by no changes in tubular injury score, between aged and young mice after 1 day post IRI (Sato et al., 2016; Kim et al., 2019), whereas in our model of low-dose of FA-induced AKI, we found an exacerbated increase in KIM-1 positive tubular cells in old mice.