BDNF and Mental deterioration: In this context, and in line with the ultimate hypothesis that higher serum levels of BDNF at earlier stages of the cognitive decline process might reflect a beneficial compensatory response to pathophysiologic insults (Weinstein et al., 2014; Ng et al., 2019), we assessed whether higher serum BDNF levels were associated with lower risk of cognitive decline 2 years later in community-dwelling older adults free of dementia.