Two further albeit later onset and usually milder leukodystrophies may benefit from astroglial gene transfer include chloride voltage gated channel 2 (CLCN2) related vacuolating leukoencephalopathy and the Oculodentodigital dysplasia with cerebral white matter abnormalities (ODDD), a hypomyelinating leukodystrophy caused by an autosomal dominant mutation in the Gap junction α 1 (Connexin-43) encoding GJA1 gene (Abrams and Scherer, 2012). The gene discussed is CLCN2; the disease is leukodystrophy.