GJA1 and leukodystrophy: Astrogliopathies caused by mutations in genes coding for astrocytic connexin hemichannels including Cx43 and Cx30 required for gap junction formation with oligodendrocytes and in genes encoding proteins associated with ion-water homeostasis, frequently present as vacuolating leukodystrophies (Lutz et al., 2009; Tress et al., 2012; van der Knaap and Bugiani, 2017).