Pelizaeus-Merzbacher disease (PMD) is a X-linked, recessive dysmyelinating leukodystrophy with the most common and severe forms caused by proteolipid protein 1 (PLP1) gene duplication (Inoue et al., 1996; Hudson, 2003; Osório and Goldman, 2018). This evidence concerns the gene PLP1 and Pelizeaus-Merzbacher spectrum disorder.