Currently, highly-expressed HO-1 has been found in various malignant tumors such as melanoma 2, thyroid cancer 5, osteosarcoma 50, breast cancer 67, lung cancer 58, bowel cancer 56, 57, 68, renal cell cancer 69, hepatoma 59, prostate cancers 63, 64, pancreatic cancer 61, and so on. This evidence concerns the gene HMOX1 and melanoma.