Downregulated histidine-rich glycoprotein (HRG), NR1H4, and transcription factor 21 (TCF21) are associated with cell communication and were identified to be induced by silencing PYCR1. Furthermore, HRG inhibits the tumor growth by facilitating clearance of dying tumor cells 53, 54; whereas NR1H4 deficiency has been shown to promote cell proliferation, inflammation, and tumorigenesis in the intestine 55, 56. This evidence concerns the gene NR1H4 and neoplasm.