It revealed dramatically increased HK3 mRNA expression in ccRCC samples that 96.6% of patients had higher levels of HK3 expression in tumor tissues than normal tissues (Figure 5B). Survival curves suggested that with elevated HK3 mRNA levels significantly correlated with poorer PFS and OS in 377 ccRCC patients from FUSCC cohort (p<0.001; Figure 5C-5D). This evidence concerns the gene HK3 and nonpapillary renal cell carcinoma.