Next, siglec15, IDO1, CD274, HAVCR2, PDCD1, CTLA-4, LAG-3, and PDCD1LG2 were selected to be immune-checkpoint-relevant transcripts and HK3 expression values of these eight genes were extracted in Figure 8G, it suggested that the immune checkpoint molecules expression was significantly elevated win high HK3 expression group compared with HK3low group of ccRCC. This evidence concerns the gene SIGLEC15 and nonpapillary renal cell carcinoma.