Spearman's correlation indicated strong relationship between HK3 and immune contexture (r=0.659, p<0.001), stromal contexture (r=0.396, p<0.001) and tumor purity (r=0.614, p<0.001) of ccRCC microenvironment (Figure 1F-H). To investigate association between HK3 and ccRCC immune microenvironment, association between abundance of immune cell infiltrations and HK3 expression was analyzed. This evidence concerns the gene HK3 and nonpapillary renal cell carcinoma.