In order to further demonstrate our hypothesis, we analyzed the expression of HK3 of all cancers (Figure 2A). Although the expression level of HK3 were significantly higher in normal tissues than in tumor tissues in CHOL, LIHC, LUAD, LUSC cohorts, HK3 expression is mostly highly expressed in tumors compared with normal sample, and the difference is more prominent in ccRCC. This evidence concerns the gene HK3 and nonpapillary renal cell carcinoma.