HK3 and lung cancer: It suggested that high expression of HK3 is significantly associated with the deteriorated outcomes, increased stage and increased of grade in 12,452 pan-cancer samples (Figure 2B-D). Furthermore, we enrolled 2,476 patients of bladder, blood, brain, breast and lung cancer with available clinical data from GEO datasets (Figure 2E). Cox regression analysis suggested that HK3 expression has closely positive association with poor prognosis.