Spearman's correlation indicated strong relationship between HK3 and immune contexture (r=0.659, p<0.001), stromal contexture (r=0.396, p<0.001) and tumor purity (r=0.614, p<0.001) of ccRCC microenvironment (Figure 1F-H). To investigate association between HK3 and ccRCC immune microenvironment, association between abundance of immune cell infiltrations and HK3 expression was analyzed. This evidence concerns the gene HK3 and neoplasm.