HK3 and nonpapillary renal cell carcinoma: Then, we focused on role of HK3, and found HK3 expression was significantly higher in 118 ccRCC primary tumors in comparison with adjacent normal tissues in GSE15641 (32 ccRCC samples, ****, p<0.001) 28, GSE53757 (72 ccRCC samples, ****, p<0.001) 29 and GSE66270 (14 ccRCC samples, ***, p<0.01) 30 (Figure 1B-D).