Next, to explore whether HK3 involved in immune-rejection microenvironment of all cancers, we extracted the expression values of siglec15, IDO1, CD274, HAVCR2, PDCD1, CTLA-4, LAG-3, and PDCD1LG2 in totally 10,201 multiple tumor tissues (Figure 8H). The gene discussed is SIGLEC15; the disease is cancer.