HK3 expression were significantly correlated with B cell, CD8+ T cell, CD4+ T cell, and especially macrophage (cor.=0.275), neutrophil (cor.=0.445), and dendritic cell infiltration (cor.=0.336), prompting a general activation in immune microenvironment of ccRCC (Figure 1I). This evidence concerns the gene HK3 and nonpapillary renal cell carcinoma.