HK3 and nonpapillary renal cell carcinoma: GSEA analysis showed transcriptional expression profiles of the 100 significant genes positive and negative correlation in a heat map (Figure 7A). In order to further study and analyze the differences in the immune molecular infiltration of the ccRCC microenvironment mediated by HK3, we combined the data of ccRCC tissues, adjacent normal tissues from TCGA database, as well as visceral and subcutaneous adipose tissue from GTEx database, to explore the relationship between HK3 activation and horizontal monocyte/macrophage infiltration, inflammatory infiltration and lipid formation processes.