As shown in Table 1, ccRCC patients with increased HK3 mRNA expression significantly correlated with advanced pT (p<0.001), pN (p<0.001), pM stage (p<0.001), AJCC stage (p<0.001) and ISUP grade (p=0.026) in FUSCC cohort. This evidence concerns the gene HK3 and nonpapillary renal cell carcinoma.