Matrix metalloproteinase 13 (MMP-13) in NPC-related exosomes upregulates vimentin and reduces cadherin to facilitate tumor invasion, metastasis and angiogenesis; on the other hand, MMP13 expression is trans-activated by hypoxia-inducible factor α (HIF1α) 6,52. The gene discussed is MMP13; the disease is nasopharyngeal carcinoma.