NOTCH2 and Alagille syndrome: Alagille syndrome patients (mutations in Jagged1 gene in 94% of patients or “Notch2” in 1-2%) were reported to rarely go onto cirrhosis and exhibit less ECM deposition than other chronic liver diseases, representing an early clue toward a role for Notch signaling pathway in the liver fibrotic response 30, 43, 44.