Although the expression of Notch1 and Notch4 decreased during the progression of hepatic fibrosis, the expression pattern of Hes1, a target gene downstream of Notch signaling, was similar to Notch3 and Jagged1, fluctuated with the progression and regression of hepatic fibrosis (Figure 1C). The gene discussed is NOTCH1; the disease is Hepatic fibrosis.