This proof-of-concept study established a high-throughput screening strategy to identify ATTECs targeting the mutant HTT protein (mHTT), which is the Huntington’s disease (HD)-causing protein.9 The study also confirmed that the ATTECs targeted mHTT to the autophagosomes for subsequent degradation without influencing the autophagy activity per se.8 Here, HTT is linked to Huntington disease.