To interrogate the translational significance of CCL5-CCR5 signaling in gliomas, we investigated a low-grade glioma (LGG)-GBM cohort from TCGA database with tumor grades, histology, subtypes and O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation information. This evidence concerns the gene CCR5 and glioblastoma.