PEAK1 and cancer: Pseudopodium-Enriched Atypical Kinase One (PEAK1 or SGK269) is a cytoskeleton-associated pseudokinase [14] and member of the new NKF3 kinase family that has been demonstrated to play key cancer cell autonomous roles in cancer initiation and progression across multiple cancer types including breast [15–17], pancreatic [14, 18], lung [19] and colon [14, 20, 21].