Varying immunoregulatory, homeostatic and repair factors (IL-1RA, LIF, SDF-1α, IL-27, IL-10, HGF, VEGF-A, VEGF-D) in the lungs and plasma were also observed to be higher or correlated with severe lung disease during the course of illness, in line with the knowledge that cytokines form biological networks that manifests biochemically and physiologically8,22. This evidence concerns the gene IL27 and lung disorder.