A recent study found that the soluble CD40 ligand (sCD40L) level of OSA patients is significantly increased, and it can be improved by continuous positive airway pressure therapy59. This means that OSA seems to have a clear correlation with the pre-atherosclerotic state, and this state can be continuously monitored by measuring the level of sCD40L. This evidence concerns the gene CD40LG and obstructive sleep apnea syndrome.