CD4 and cancer: T helper type 1 (Th1) cells, M1 macrophage (M1), and dendritic cell (DC) showed significantly less infiltration among the anti-cancer immune cells in miR-29a expressing GC (Fig. 4C; p = 0.006, p = 0.007 and p < 0.001, respectively), whereas other immune cells such CD8 T cells, CD4 T cells, and natural killer (NK) cells showed more infiltration (Fig. 4C).