SUV39H1 and Hyperglycemia: As mentioned above, SUV39H1 is responsible for trimethylation at H3K9 to H3K9me334; our results show that its expression and binding at Rac1 promoter are increased in hyperglycemia, and silencing of Suv39H1 attenuates increase in 5hmC, which is a product of dynamic DNA methylation.