The aim of the present study was to evaluate the mRNA and protein expression of AMH, a well-defined marker of ovarian reserve, and FSH receptor in mural granulosa cells (MGCs) of FMR1 premutation carriers and noncarriers undergoing in vitro fertilization (IVF) treatments and in FMR1 premutation-transfected tumor cells in order to gain insight into the pathophysiologic mechanisms underlying FXPOI. Here, FMR1 is linked to neoplasm.