It was reported that chemotherapy-elicited exosomes are enriched in ANXA6 that facilitates the establishment of lung metastasis, and the patients with elevated ANXA6 levels have progressive disease in the neoadjuvant setting, which strongly suggests that chemoresistance is potentially related with exosome-associated ANXA6 and it was of cancer cell origin [26]. The gene discussed is ANXA6; the disease is cancer.