To know the role of miR-7641 in breast cancer stemness and glycolysis by HIF-1α, breast cancer cells were in the presence of the sEVs with miR-7641 or HIF-1α overexpression, and cell survival ability was assayed by CCK8 and it was found that cell survival ability was suppressed in the cells with CAFs/miR-7641 sEVs and HIF-1α could recue the progression (Fig. 6A, B). Here, HIF1A is linked to breast cancer.