p53 is the most frequently mutated gene in human cancers.544,545 Furthermore, in some cell types, p53 can enhance apoptosis, whereas in other cell types, p53 intensifies cell cycle progression.546 p53 inactivation leads to intratumoral heterogeneity and, compared to wild-typep53, mutant p53 may exhibit gain-of-function mutations related to apoptosis, anti-oxidant activity or the epithelial-to-mesenchymal transition (EMT) in addition to its DNA damage repair functions. This evidence concerns the gene TP53 and cancer.