Because of their intrinsic characteristic of genomic instability, cancer cells may trigger innate immunity through activation of a series of inflammatory pathways aimed at facilitating the targets of cytotoxic lymphocytes,394 such as the report showing that IFN-gamma is critical for cytotoxic T cell-dependent genome immunoediting of cancer cells.395 Insufficient genome integrity due to DNA repair and replication defects may also activate the innate immune response. This evidence concerns the gene IFNG and cancer.