A recent study found that DNA-PKcs, a well-known protein in the non-HEJR pathway that plays a pivotal role in genome stability, also has functions in immune escape.410 In addition, p53, a vital cancer suppressor, activates the innate immune response against cancer cells and can directly control immunosurveillance to achieve successful cancer therapy.411 Thus, DDR-related sensors and protein complexes as well as the immune escape mechanism are very important to cancer immune therapy. The gene discussed is TP53; the disease is cancer.