We noticed for the proliferative subtype strong interactions between CAFs (FB_COMP, FB_COL27A1 and FB_SERPINE1) and tumour subcluster Tum_KRT17 (Fig. 9D), characterised by canonical Wnt (Wnt5A-FZD2/FZD3/FZD5), fibroblast growth factor (FGF7-FGFR2/FGFR3, FGFR1-FGF9/NCAM1) and transforming growth factor β (TGFB3-TGFBR2/TGFBR3) signalling, all promoting tumour growth. This evidence concerns the gene FZD2 and neoplasm.