Beside the high prevalence of interactions involving fibroblasts and endothelial cells, the immunoreactive tumour was, in contrast to the other 3 molecular subtypes, characterised by a high number of interactions involving CD8+ effector memory cells (TC_GZMK), early M1 macrophages (M_CCR2) and tumour-associated macrophages (M_CCL18). Here, CCR2 is linked to neoplasm.