ARHGEF10 and nervous system disorder: The 8p23.3P23.2 deletion region contains 6 OMIM genes, including FBXO25, DLGAP2, CLN8, ARHGEF10, ERICH1-AS1, and MYOM2. Currently, the DLGAP2, CLN8, ARHGEF10 genes on the 8p23.3 chromosome region are known to be expressed in the brain, and are considered as candidate genes for neurological diseases (Table 1).