To address this, we will use our state-of-the-art unbiased proteomic (mass spectrometry) based platform to conduct a detailed characterization and assessment of molecular changes in protein expression levels, molecular pathways and biofunctions significantly altered in the cerebrovessels of AD patients compared to healthy control cases from different APOE genotype backgrounds (E2/E2, E2/E3, E3/E3, E3/E4 and E4/E4). This evidence concerns the gene APOE and Alzheimer disease.