INS and ischemia: It was reported in mice that lower dosages of NMN (100 mg/kg/d) were better compared with larger doses (300 mg/kg/d) for body weight, body composition, insulin sensitivity, bone mineral density, and physical activity [7], and treatment with 62.5 mg/kg NMN was better than that with 125–500 mg/kg NMN for ischemia-induced brain damage [8].