As an example, Chronic myeloid leukemia (CML) was found to be characterized by the BCR-ABL1 translocation and showed later to be a paradigmatic disease amenable to functional cure with tyrosine-kinase inhibitors (TKIs) targeting the ABL1 kinase [10, 11]. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.