Similarly, the ESR1 gene represents a low-risk-factor, SPP1 gene represent a high-risk factor and therefore liver cancer patients that show HALLMARK PANCREAS BETA CELLS and HALLMARK ESTROGEN RESPONSE LATE pathway activated and the HALLMARK ADIPOGENESIS, HALLMARK FATTY ACID METABOLISM, HALLMARK BILE ACID METABOLISM, HALLMARK XENOBIOTIC METABOLISM and HALLMARK PEROXISOME pathways inhibited have a better prognosis. Here, SPP1 is linked to liver cancer.