Although it has been reported lncRNA TBX5-AS1 as antisense RNA of TBX5 could serve as potential diagnostic biomarkers for NSCLC and could inhibit the tumor progression of NSCLC through inactivating the PI3K/AKT pathway [27–29], the exact mechanism between TBX5-AS1 and TBX5 in LUAD has not been reported and there are no studies used eRNA as a biomarker for LUAD. Here, TBX5 is linked to neoplasm.