In T-cell acute lymphoblastic leukemia (T-ALL), it was also reported that the eRNA ARIEL could recruit mediator proteins to the ARID5B enhancer, thereby boosting enhancer-promoter interactions and activating the expression of ARID5B. These activities led to the aberrant activation of the TAL1-induced transcriptional program and myc oncogenic signals [21]. Here, ARID5B is linked to acute lymphoblastic leukemia.